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. 2022 Nov 15;12:19547. doi: 10.1038/s41598-022-23793-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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An unweighted UniFrac principal coordinates analysis shows an ordination of microbiome data, colored by self-reported FACT-Cog subscale perceived cognitive impairments status. Each dot represents the fecal microbiome of one participant’s sample. Purple dots indicate participants with high perceived cognitive impairment (FACT-Cog subscale perceived cognitive impairments < 60), whereas yellow dots represent participants with low perceived cognitive impairment. PCo1 accounts for 12.5% of the observed variation, while PCo2 accounts for 6.5% of observed variation.