TABLE 1.

Differences between aptamers and monoclonal antibodies.

	Aptamer	Monoclonal antibody
Size	∼12–30 kDa	∼150–170 kDa
Manufacturing	Chemical synthesis	Cell culture
Stability	Chemically stable in a wide range of temperatures; reversibility of folding	Susceptible to high temperatures and pH changes; generally non-reversible folding
Immunogenicity	Non-immunogenic	Unwanted immunogenicity
Modifiability	Easily modify without affinity loss	Conjugated with signaling or binding molecule