Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 19;81(12):1669–1677. doi: 10.1136/ard-2022-222871

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Potential pathogenesis across successive RA stages from multiomics perspective. (A) Potential mechanisms by which gut microbial dysbiosis play roles in RA pathogenesis through hurting hone tissue and increasing inflammation. The driving species, microbial dysfunction and related metabolites were extracted from figure 1B. The red or blue box of metabolites represents their speculated elevation or depletion according to the KEGG map. The dotted line represents the speculated effects of microbial and metabolic variation on arthritis pathogenesis. (B) The most representative effects of microbial dysbiosis and metabolic disorders on RA progression across successive stages. KEGG, Kyoto Encyclopaedia of Genes and Genomes; RA, rheumatoid arthritis.