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. 2022 Feb 9;71(12):2539–2550. doi: 10.1136/gutjnl-2021-325150

Figure 1.

Figure 1

Follistatin-like protein 1 (FSTL1) expression is increased in macrophage of liver fibrosis tissues. Human dada (A–D) and mice data (E–H): (A) FSTL1 messenger RNA (mRNA) expression and (B) protein expression in human liver samples; (C) dual-immunofluorescence staining of FSTL1 and CD68 in liver samples; (D) liver FSTL1 expression among patients with HCV or non-alcoholic steatohepatitis (NASH)-induced liver fibrosis as determined by microarray data; (E) FSTL1 mRNA expression and (F) protein expression in murine livers; (G) FSTL1 mRNA expression in isolated mice liver macrophages; (H) dual-immunofluorescence staining of FSTL1 and CD68 in murine livers. Human samples: control (n=18), mild fibrosis (n=20), advanced fibrosis (n=13); mice samples (n=6–8 per group). Data were presented as mean±SEM; scale bars, 50 µm; **p<0.01, ***p<0.001. BDL, bile duct ligation; CCl4, carbon tetrachloride; MCD, methionine-deficient and choline-deficient diet.