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. 2022 Sep 16;82(22):4288–4298. doi: 10.1158/0008-5472.CAN-21-2483

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 4. Masking of EGFR and CD3 binding domains in CI107 attenuates cytokine release in PBMCs cocultured with human colorectal cancer cells. HCT116-Luc2 cells were cocultured with human PBMCs (Donor 4) and treated with increasing concentrations of CI107, activated TCB (Act-TCB), or non–EGFR-targeted control CI128. After 16 hours of culture, cytokine release was measured for IFNγ (A), IL2 (B), IL6 (C), MCP-1 (D), and TNFα (E) using a U-PLEX plate. — Masking of EGFR and CD3 binding domains in CI107 attenuates cytokine release in PBMCs cocultured with human colorectal cancer cells. HCT116-Luc2 cells were cocultured with human PBMCs (Donor 4) and treated with increasing concentrations of CI107, activated TCB (Act-TCB), or non–EGFR-targeted control CI128. After 16 hours of culture, cytokine release was measured for IFNγ (A), IL2 (B), IL6 (C), MCP-1 (D), and TNFα (E) using a U-PLEX plate.