Figure 6.

While GCDCA causes comparable contraction of virulent and attenuated MNV strains, low pH causes variable conformational changes. (A, D, G) Sections of the image reconstructions of all three strains at pH 7.4 without bile or metals present. Note that all three have floating P domains. The linker between the shell and the P domain is more visible in MNV1 because it is a lower resolution structure where those details are not lost. (B, E, H) Magnified views of the MNV P domains at pH 7.4 in the presence of GCDCA (C, F, I) Representative images of a magnified view of the MNV P domains at pH 5.0. In the bottom CR6 image, arrow 1 indicates the weak density of the P domains and arrow 2 indicates the splaying of P1 domains at the base that is not observed for MNV1 or WU23.