TABLE 2.

List of highly enriched proteins (q-value <0.05 & z-score ± 1.96) that also have highly enriched transcripts (FDR <0.05 & fold change >1.5) in our previously published work (Potus et al., 2018), in data published from the right ventricle (RV) from Fischer rats + Sugen5416 + hypoxia (SUHx) or Sprague Dawley (SD) rats + SUHx (Suen et al., 2019), or from RV SD + MCT rats and SD + SUHx (Park et al., 2021).

Annotation		Protein			Potus et al. RNA		Suen et al. RNAseq		Park et al. RNAseq
Description	Symbol	zscore	Log FC	q-value limma	MCT Log FC	MCT p-value	Fischer + SUHx FC	SUHx FC	SD + SUHx FC	SUHx FC
natriuretic peptide A	Nppa	7.55	8.52	6.73E-07	4.19	1.55E-04	47.56	-	—	—
thrombospondin 4	Thbs4	5.56	6.38	8.00E-06	4.4	2.80E-07	16.51	10.11	1.8	1.3
periostin	Postn	3.83	4.5	1.99E-05	4.56	1.67E-17	8.84	7.06	2.12	1.18
latent transforming growth factor beta binding protein 2	Ltbp2	2.67	3.25	6.17E-03	4.16	3.72E-16	7.5	6.18	1.75	1.22
heme oxygenase 1	Hmox1	4.59	5.33	2.45E-06	2.05	1.67E-17	3.54	—	1.86	1.25
TSC22 domain family, member 1	Tsc22d1	3.82	4.5	1.12E-03	2.1	1.82E-11	2.77	2.59	1.62	1.04
glycoprotein nmb	Gpnmb	3.21	3.83	2.24E-04	2.35	8.47E-08	2.55	—	2.22	1.26
ATPase Na+/K+ transporting subunit alpha 2	Atp1a2	−3.47	−3.38	7.10E-06	−2.23	1.25E-04	0.37	0.32	−1.66	—
glutathione S-transferase zeta 1	Gstz1	−1.97	−1.76	1.18E-03	−2.38	9.02E-23	0.34	-	−1.41	—
collagen type XVIII alpha 1 chain	Col18a1	2.59	3.17	1.02E-05	1.61	8.08E-13	-	-	3.22	—
cysteine and glycine-rich protein 2	Csrp2	3.1	3.72	1.08E-02	2.02	3.69E-05	-	-	1.81	2.09
S100 calcium-binding protein A4	S100a4	2.43	2.99	1.11E-04	1.93	1.55E-04	-	-	1.68	1.04
ankyrin repeat domain 2	Ankrd2	4.04	4.74	3.28E-06	2.49	1.27E-02	-	-	1.61	—
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Plod2	6.89	7.82	6.73E-07	2.3	3.43E-15	-	3.36	1.91	1.19
tenascin C	Tnc	5.18	5.96	7.37E-03	2.53	3.08E-07	-	-	1.91