Table 4.

Multivariate logistic regression analysis for evaluation of risk factors for relapse after discontinuation of biologics in pediatric patients with Crohn’s disease. Multivariate analysis was performed by selecting a variable with P < 0.1 in univariable analysis.

Parameter	Univariate analysis				Multivariate analysis
	P-value	Odds ratio	95% CI		P-value	Odds ratio	95% CI
			Lower	Upper			Lower	Upper
Age at diagnosis	0.056	0.712	0.503	1.009	0.047	0.807	0.653	0.997
Gender	0.022	0.056	0.005	0.664
SES-CD a at diagnosis	0.056	0.712	0.503	1.009
Immunomodulator status at D/C	0.452	2.298	0.262	20.113
Duration of biologics treatment	0.030	0.510	0.278	0.936	0.018	0.600	0.392	0.918
Monocyte percentage of WBC	0.004	2.018	2.006	2.030	<0.001	2.012	2.005	2.019
Absolute count of monocyte	0.689	1.207	0.480	3.037
Monocyte/PMN ratio	0.040	68.698E+11	1.524	4.963E+23	0.002	4.320E+14	287572.010	6.489E+23
Hematocrit at D/C	0.151	0.838	0.659	1.067
ESR at D/C	0.952	0.997	0.914	1.088
Albumin at D/C	0.003	0.515	0.359	0.807	0.002	0.674	0.483	0.983
CRP at D/C	0.738	0.461	0.005	42.985
Fecal calprotectin at D/C	0.001	2.073	1.353	3.177	<0.001	1.839	1.323	2.556
SES-CD at D/C	0.297	1.383	0.751	2.546

^aThe simple endoscopic score for Crohn’s disease (SES-CD) assesses the size of mucosal ulcers, the ulcerated surface, the endoscopic extension, and the presence of stenosis.

^bPediatric Crohn’s disease activity index (PCDAI) score can range from 0 to 100, with higher scores signifying more active disease. A score of <10 indicates consistent with inactive disease, 11–30 indicates mild disease, and >30 indicates moderate-to-severe disease.

Bold values mean statistically significant values with p-value <0.05.