Longitudinal Mediation analysis examining the pathway between household wage loss reported in May–June 2020 and youth depressive symptoms reported in May 2021. Three longitudinal mediation analyses were run to examine the pathway from household wage loss (at the beginning of data collection; May–June 2020) to depressive symptoms (a year later; May 2021), using mediator data from intermittent survey data (August 2020–March 2021). (A) Mediation Model 1 examines youth-reported financial stress as a mediator. (B) Mediation Model 2 examines familial factors (family conflict, parental monitoring, and parent-reported conflict between family and workplace responsibilities) as mediators. (C) Mediation Model 3 examines both youth-reported financial stress and familial factors as mediators. Sociodemographic data (age, sex, race, ethnicity, pre-pandemic household income) was regressed out of household wage loss (independent variable). General worries about coronavirus were regressed out of youth-reported financial stress (mediator). ∗ indicates P-value less than 0.05. ∗∗∗ indicates P-value less than 0.001.