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. Author manuscript; available in PMC: 2023 Sep 6.
Published in final edited form as: Cell Metab. 2022 Sep 6;34(9):1394–1409.e4. doi: 10.1016/j.cmet.2022.08.014

Figure 6. Chromatin contacts link T2D risk variants to target genes with cell-type specific stratification.

Figure 6.

A, Cell type-specificity of putative causal variants and their target gene. The variant-containing gene-OCR pairs with high cell-specificity (specificity >= 0.5) were labelled with target gene name for each cell type B, The gene-causal-variant pairs were clustered based on cell-type specificity C, Cell type-specific chromatin looping between causal variants (rs7482891, rs4929964 and rs4929965) and target genes INS and TRPM5 and the T2D TH (rs4929965) locus. The chromatin loops that connect causal variants and target genes are highlighted with cell-type specific color (acinar: red, alpha: green and beta: blue), with hue scale indicating Hi-C interaction frequency. D, Cell-specific chromatin looping between variant rs4234731 and the target gene WFS1 at the T2D rs10937721 locus. The chromatin loops that connect putative causal variants and target genes are highlighted with cell-type specific color (acinar: red, alpha: green and beta: blue) with the hue scale indicating the Hi-C interaction frequency.