TABLE 4.

Comparison of effects of anti-CD14 MAbs 18E12 and My-4 on the production of IL-10 by monocytes stimulated with LPS, H. influenzae, or S. pneumoniae^a

MAb	LPS			H. influenzae			S. pneumoniae
	n	IL-10 concn (pg/ml)	P	n	IL-10 concn (pg/ml)	P	n	IL-10 concn (pg/ml)	P
Control	10	442 ± 267		9	1,443 ± 1,138		9	820 ± 666
18E12	10	94 ± 64	0.001	9	753 ± 413	0.044	9	588 ± 575	0.038
Control	7	440 ± 254		7	1,334 ± 530		9	1,033 ± 693
My-4	7	91 ± 79	0.004	7	732 ± 429	0.033	9	1,255 ± 1,315	0.447

^aAdherent monocytes were stimulated with LPS (10 ng/ml), heat-killed H. influenzae (10⁶ organisms/ml), or heat-killed S. pneumoniae (10⁶ organisms/ml) for 24 h in the presence of the indicated MAb.