Table 2.
Top colocalization analysis results for CVD risk factor-associated CpGs.
| CpG | Chr | Position | Annotated Gene of CpGs | Relation to CpG island* | Distance to TSS | CVD risk factors associated with CpGs in EWAS catalog | Colocalized traits | Colocalized cis-mQTL variants | PPFC | PPE % |
|---|---|---|---|---|---|---|---|---|---|---|
| cg14509967 | 17 | 48601772 | HOXB6 | S_shelf | 6021 | BMI | BMI | rs9299 | 1 | 100 |
| cg01856529 | 12 | 54259306 | CBX5 | 28,364 | HDL | BMI | rs4759073 | 0.9869 | 74.42 | |
| cg27087650 | 19 | 44752538 | BCL3 | N_shore | 4833 | BMI | CAD | rs62117206 | 0.889 | 46.72 |
| cg05337441 | 2 | 21043695 | APOB | N_shore | 42,266 | LDL | CAD | rs668948 | 0.7996 | 41.29 |
| cg03676485 | 7 | 2524181 | LFNG | Island | 11,652 | HDL | DBP | rs4632959 | 0.9999 | 100 |
| cg14099685 | 11 | 47524515 | CUGBP1 | 58,578 | SBP | DBP | rs34312154 | 0.993 | 57.7 | |
| cg21506299 | 6 | 136784086 | MAP3K5 | 227,040 | BMI | HDL | rs6924387 | 0.9978 | 99.74 | |
| cg27087650 | 19 | 44752538 | BCL3 | N_shore | 4833 | BMI | HDL | rs1531517 | 0.9961 | 59.67 |
| cg27087650 | 19 | 44752538 | BCL3 | N_shore | 4833 | BMI | LDL | rs4803750 | 0.9989 | 100 |
| cg03725309 | 1 | 109214962 | SARS1 | S_shore | 1069 | BMI:SBP:TG | LDL | rs4970829 | 0.9962 | 100 |
| cg03676485 | 7 | 2524181 | LFNG | Island | 11,652 | HDL | SBP | rs4632959 | 0.9999 | 99.99 |
| cg20278790 | 20 | 59008418 | CTSZ | S_shore | 13,233 | WC | SBP | rs151343 | 0.9979 | 100 |
| cg11554650 | 6 | 30685413 | PPP1R18 | N_shore | 9024 | BMI | T2D | rs2516396 | 0.9835 | 100 |
| cg00973118 | 16 | 324569 | AXIN1 | N_shore | 37,129 | BMI | T2D | rs8049265 | 0.9505 | 99.33 |
| cg27087650 | 19 | 44752538 | BCL3 | N_shore | 4833 | BMI | TG | rs4803750 | 0.9988 | 98.56 |
| cg14099685 | 11 | 47524515 | CELF1 | 58,578 | SBP | TG | rs34312154 | 0.9927 | 54.52 |
The top two colocalization results are presented for each outcome trait of interest (BMI, SBP, DBP, HDL, LDL, TG, T2D, & CAD). BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; DBP, high density lipoprotein cholesterol; LDL, low density lipoprotein cholesterol; TG, triglyceride; T2D, type 2 diabetes; CAD, coronary artery disease; PPFC, posterior probability of colocalization; PPE, proportion of PPFC explained by the listed SNP.
*Shore is region from 1 to 2 Kb away from a CpG island and shelf is located at 2–4 Kb from a CpG island. Prefixes N_ and S_ represent north (i.e., upstream) and south (i.e., downstream) regions relative to a CpG island.
TSS, transcription start site.