Table 2. Spearman Correlation Coefficients (r_s) and Significance p Values of Wastewater Measures (3-week moving average) against Clinical Case Data (7-day moving average) for WASD and UM County-Level Data^a.

	UM composite (Jan 2021-Nov 2021)		UM grab (Jan 2021-Nov 2021)
wastewater measure	rs	p value	rs	p value
V2G-qPCR
SARS-CoV-2 (N3)	0.69	<0.001	0.49	<0.001
PMMoV	0.07	0.642	0.16	0.308
B2M	0.01	0.925	0.06	0.710
fecal coliform	0.00	1.00	0.13	0.396
SARS-CoV-2/PMMoV	0.76	<0.001	0.54	<0.001
SARS-CoV-2/B2M	0.86	<0.001	0.71	<0.001
SARS-CoV-2/fecal coliform	0.59	<0.001	0.17	0.259
RT-qPCR
SARS-CoV-2 (N1)	0.38	0.012	0.56	<0.001
SARS-CoV-2 (N1)/PMMoV	0.24	0.129	0.52	<0.001
SARS-CoV-2 (N1)/B2M	0.17	0.298	0.50	<0.001
SARS-CoV-2 (N1)/fecal coliform	0.35	0.022	0.34	0.026
SARS-CoV-2 (ORF1ab)	0.35	0.022	0.54	<0.001
SARS-CoV-2 (ORF1ab)/PMMoV	0.27	0.090	0.48	0.001
SARS-CoV-2 (ORF1ab)/B2M	0.22	0.168	0.48	0.001
SARS-CoV-2 (ORF1ab)/fecal coliform	0.36	0.021	0.28	0.071

	WASD Composite (March 2020- Nov 2021)		WASD Composite (Jan 2021-Nov 2021)
SARS-CoV-2	0.88	<0.001	0.86	<0.001
SARS-CoV-2/PMMoV	0.79	<0.001	0.76	<0.001

^aComparisons provided for composite versus grab samples for UM samples and between consistent periods of record for both UM and WASD data (January 2021 to November 2021). The statistics are also provided for the complete period of record (March 2020 to November 2021) for the WASD data. B2M and PMMoV analyzed by V2G-qPCR. WASD SARS-CoV-2 levels correspond to weighted average (by population served) for all three major wastewater treatment plants in the county, whereas the UM data corresponds to SARS-CoV-2 levels measured at the CDWWTP only.