Variables |
All patients (n = 71) |
Conventional treatment (n = 38) |
Burosumab treatment (n = 33) |
Comparison between conventional treatment and burosumab (p) |
Sex, n (%) |
|
|
|
|
Male |
30 (42.3) |
16 (42.1) |
14 (42.4) |
|
Female |
41 (57.7) |
22 (57.9) |
19 (57.6) |
0.98 |
Age at XLH treatment onset (years), mean ± SD |
5.45 ± 4.34 |
2.92 ± 3.0 |
8.36 ± 3.81 |
0.00001 |
XLH treatment duration (months), mean ± SD |
70.5 ± 49.2 |
97.9 ± 46.9 |
38.9 ± 29.0 |
0.0001 |
Alkaline phosphatase level (IU/L), mean ± SD |
364.4 ± 138.9 |
385.8 ± 147.7 |
339.8 ± 125.7 |
0.17 |
Age at dental follow‐up onset (years), mean ± SD |
7.86 ± 3.76 |
6.58 ± 3.33 |
9.33 ± 3.72 |
0.004 |
Dental follow‐up duration (months), mean ± SD |
41.5 ± 27.5 |
53.9 ± 31.9 |
27.2 ± 9.6 |
0.0009 |
Number of dental abscess per month of dental follow‐up (n/month), mean ± SD |
0.03 ± 0.04 |
0.04 ± 0.05 |
0.01 ± 0.03 |
0.04 |
Number of maxillofacial cellulitis per month of dental follow‐up (n/month), mean ± SD |
0.004 ± 0.02 |
0.007 ± 0.02 |
0.002 ± 0.008 |
0.23 |
Dental caries during dental follow‐up, n (%) |
13 (18.3) |
7 (18.4) |
6 (18.2) |
0.98 |