Table 1.
Characteristics of COPDGene study participants
| Demographic (mean ± SD) | Mild to very Severe COPD (GOLD 1–4) (N = 4248) |
Smoking controls No COPD (GOLD 0) (N = 4116) |
Non-smoking controls (N = 104) |
|---|---|---|---|
| Age (years) | 63.1 ± 8.6 | 56.7 ± 8.4 | 62.2 ± 9.4 |
| Percent Male N (%) | 2,393 (56.3) | 2,194 (53.3) | 32 (30.8) |
| Race N (%) | |||
| Non-Hispanic White | 3,296 (77.6) | 2,422 (58.8) | 97 (93.3) |
| African American | 952 (22.4) | 1,694 (41.2) | 7 (6.7) |
| Pack Years | 51.4 ± 27.0 | 37.3 ± 20.2 | – |
| Current Smoker N (%) | 1,833 (43.1) | 2,441 (59.3) | – |
| BMI (kg/m2) N (%) | |||
| Underweight (< 18.5) | 106 (2.5) | 27 (0.66) | 1 (0.96) |
| Healthy Weight (18.5 ≤ BMI < 25) | 1,369 (32.2) | 1,029 (25.0) | 31 (29.8) |
| Overweight (25 ≤ BMI < 30) | 1,435 (33.8) | 1,530 (37.2) | 38 (36.5) |
| Obese (BMI ≥ 30) | 1,338 (31.5) | 1,530 (37.2) | 34 (32.7) |
| Inhaled Corticosteroid Use N (%) | 1,880 (45.0) | 224 (5.5) | 0 (0) |
| Severe Exacerbations N (%) | 818 (19.3) | 174 (4.2) | 0 (0) |
| Number of Comorbidities N (%) | |||
| 0 | 1,374 (32.4) | 1,965 (47.8) | 49 (47.1) |
| 1–2 | 2,325 (54.8) | 1,883 (45.8) | 51 (49.0) |
| 3 + | 545 (12.8) | 266 (6.5) | 4 (3.8) |
| Percent Emphysema | 11.7 ± 12.3 | 2.0 ± 2.5 | 1.7 ± 2.2 |
| FEV1 Percent Predicted | 57.6 ± 22.7 | 97.4 ± 11.4 | 102.7 ± 13.6 |
| Six Minute Walking Distance (m) | 377.2 ± 124.5 | 455.7 ± 106.3 | 513.0 ± 100.0 |
BMI, body mass index; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 s; SD, standard deviation