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. 2022 Nov 14;17:31. doi: 10.1186/s13062-022-00345-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — In vivo and ex vivo assessment of dual-sEVs by nuclear techniques. A Blood half-life. B Ex vivo biodistribution of dual-sEVs in a U87 xenograft mouse model 24 h after tracer injection. Detailed radioactivity in the brain (control organ) compared to U87 tumor tissue. * p < 0.05. C Ratio of dual-SEV uptake in U87 tumor tissue to non-target tissues at 24 h. D Excretion profile of dual-sEVs in urine and feces collected from the animal 24 h post-injection. Radioactivity in tissues is expressed as % ID/g. Data are represented as mean ± SD