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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Adv Drug Deliv Rev. 2022 Sep 2;189:114524. doi: 10.1016/j.addr.2022.114524

Fig. 9.

Fig. 9.

Studies on Yb-based NPs (YbNP@SiO2-NTA) CAs. a) Sketch map of synthesis of UCNP@SiO2-NTA. b) X-ray attenuation curves of healthy and cracked bone. c-e) Spectral CT images of cracked bones in vitro at 40 keV, 70 keV, 140 keV. f, g) iodine base image (gray and color). h) Conventional CT and spectral CT images at different times after intramuscular injection of YbNP@SiO2-NTA and YbNP@SiO2-NH2. i) Curves of iodine density with against time at different bone locations. j) Curves of CT values with different times at different bone locations (GE Healthcare). Reproduced from Ref. [125] Copyright 2016, ACS Nano.