Fig. 5.

Performance of ssPA methods on the full pathway set (including redundancy) based on 3 randomly enriched pathways. a Top panel OC $\ge$ 0.25, b bottom panel OC $\ge$ 0.5. All metabolites in enriched pathways have identical effect size. Points show performance metrics averaged across 200 iterations. Shaded intervals represent average SEM. Dotted lines represent conventional pathway analysis methods, and dashed lines represent clustering/dimensionality-reduction based methods