Table 2.

Sensitivity, specificity, PPV and NPV of self-report, pharmacy refill and RTMM at viral load ≥ 20 copies/ml

Cut-off %
Adherence measure	Viral load		Sensitivity	Specificity	PPV	NPV
	≥ 20	< 20
Self-report
< 80%	4	0	5.8	100	100	70.3
≥ 80%	65	154
Pharmacy refill
< 80%	14	26	19.7	83.6	35.0	70.0
≥ 80%	57	133
RTMM
< 80%	10	16	41.7	70.9	38.5	73.6
≥ 80%	14	39

Cut-off 85%
	Viral load		Sensitivity	Specificity	PPV	NPV
	≥ 20	< 20
Self-report
< 85%	4	1	5.8	99.3	80.0	70.2
≥ 85%	65	153
Pharmacy refill
< 85%	17	29	23.9	81.8	37.0	70.6
≥ 85%	54	130
RTMM
< 85%	11	19	45.8	65.4	36.7	73.5
≥ 85%	13	36

Cut-off 90%
	Viral load		Sensitivity	Specificity	PPV	NPV
	≥ 20	< 20
Self-report
< 90%	4	1	5.8	99.3	80.0	70.2
≥ 90%	65	153
Pharmacy refill
< 90%	21	34	29.6	78.6	38.2	71.4
≥ 90%	50	125
RTMM
< 90%	12	22	50.0	60.0	35.3	73.3
≥ 90%	12	33

Cut-off 95%
	Viral load		Sensitivity	Specificity	PPV	NPV
	≥ 20	< 20
Self-report
< 95%	5	8	7.2	94.8	38.5	69.5
≥ 95%	64	146
Pharmacy refill
< 95%	29	40	40.8	74.8	42.0	73.9
≥ 95%	42	119
RTMM
< 95%	13	26	54.2	52.7	33.3	72.5
≥ 95%	11	29

Cut-off 100%
	Viral load		Sensitivity	Specificity	PPV	NPV
	≥ 20	< 20
Self-report
< 100%	12	22	17.4	85.7	35.3	69.8
100%	57	132
Pharmacy refill
< 100%	35	62	49.3	61.0	36.1	72.9
100%	36	97
RTMM
< 100%	18	39	75.0	29.1	31.6	72.7
100%	6	16

PPV positive predict value, NPV negative predict value, RTMM real time medication monitoring.