Table 2.
Clinical characteristics and embryo development of all patients in SERa + and SERa– cycles
| Characteristic | SERa + cycles (n = 545) | SERa- cycles (n = 545) | t/χ2/z | P-value |
|---|---|---|---|---|
| Age, y | 33.90 ± 5.14 | 33.97 ± 5.63 | -0.208 | 0.835 |
| BMI, kg/m2 | 22.10 ± 3.11 | 22.13 ± 3.12 | -0.152 | 0.879 |
| Years infertile, y | 5.62 ± 3.92 | 5.72 ± 4.23 | -0.405 | 0.686 |
| Type of infertility | 0.381 | 0.537 | ||
| Primary infertility | 49.20 (320/545) | 50.80 (330/545) | ||
| Secondary infertility | 51.10 (225/545) | 48.90 (215/545) | ||
| Basal FSH, IU/L | 8.15 ± 3.53 | 8.17 ± 3.50 | 0.923 | |
| Protocol, % | 11.340 | 0.003 | ||
| Agonist | 58.00 (316/545) | 60.60(330/545) | ||
| Antagonist | 27.20 (148/545) | 31.00 (169/545) | ||
| Others | 14.90 (84/545) | 8.40 (46/545) | ||
| Total dose of Gn, IU | 2199.13 ± 928.94 | 2071.28 ± 880.37 | 2.324 | 0.020 |
| Initial dose of Gn, IU | 192.82 ± 67.01 | 188.96 ± 63.86 | 0.970 | 0.332 |
| Duration of Gn, days | 10.68 ± 2.60 | 10.35 ± 2.94 | 1.956 | 0.051 |
| No. of oocytes retrieved, n | 12.30 ± 7.19 | 9.89 ± 7.14 | 0.873 | < 0.001 |
| No. of SERa- oocytes, n | 9.16 ± 7.12 | 9.89 ± 7.14 | -1.690 | 0.091 |
| Serum oestradiol concentration, ng/L | 2822.27 ± 1501.84 | 2434.00 ± 1523.53 | 0.853 | < 0.001 |
| Serum progesterone concentration, ug/L | 0.95 (0.66–1.31) | 0.94 (0.64–1.33) | -0.093 | 0.926 |
| Endometrial thickness, mm | 11.25 ± 2.93 | 11.14 ± 3.08 | 0.457 | 0.539 |
| 2PN fertilization rate, % | 58.73 ± 21.74 | 58.39 ± 29.06 | 0.240 | 0.811 |
| Poly-pronucleus zygote rate, % | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | -1.663 | 0.102 |
| Cleavage rate from 2PN zygote, % | 88.52 ± 21.68 | 86.79 ± 26.74 | 1.171 | 0.242 |
| Good-quality embryo rate, % | 24.20(1,110/3,581) | 28.30(828/2,925) | 15.451 | < 0.001 |
| No. of available embryo, n | 3.64 ± 2.43 | 3.15 ± 2.32 | 3.396 | 0.001 |
| Blastocyst formation rate, % | 47.27 ± 33.76 | 46.77 ± 35.48 | 0.185 | 0.853 |
| Cancellation rate, % | 31.70 (173/545) | 34.10 (186/545) | 0.702 | 0.402 |
Note: Data are presented as mean ± SD or median (interquartile range) for continuous variables and % (n/N) for categorical variables
The 2PN fertilization rate = number of 2PN zygotes /number of oocytes retrieved; poly-pronucleus zygotes rate = number of poly-pronucleus zygotes/number of oocytes retrieved; cleavage rate from 2PN zygote = number of cleavages from 2PN/number of zygotes; good-quality embryo rate = number of top-quality embryos/number of cleavage-stage embryos from 2PN; percent blastocyst formation = No. of blastocyst formation/ No. of blastocyst culture
BMI body mass index, FSH Follicle Stimulating Hormone, Gn gonadotrophin
Other protocols were minimal stimulation with recombinant follicle-stimulating hormone or human menopausal gonadotrophin, clomiphene citrate,and natural cycle