Table 4.
Comparison of embryo development, pregnancy and neonatal outcomes between SERa + and SERa-oocytes from 545 SER + positive cycles (n = 6,706)
| Characteristic | SERa + oocytes (n = 1,715) | SERa- oocytes (n = 4,991) | P-value* | |
| Percentage, % | 25.57 (1,715/6,706) | 74.43 (4,991/6,706) | - | |
| 2PN fertilization rate, % | 61.40 (1,053/1,715) | 55.90 (2,792/4,991) | < 0.001 | |
| Poly-pronucleus zygote rate, % | 2.10 (36/1,1715) | 0.80 (41/4,991) | < 0.001 | |
| Good-quality embryo rate, % | 32.30 (311/963) | 30.50 (799/2,618) | 0.309 | |
| Blastocyst formation rate, % | 51.30 (241/470) | 55.60 (808/1452) | 0.098 | |
| Only SERa + embryo transfer | Mixed SERa + and SERa- embryo transfer | Only SERa- embryo transfer | ||
| No. of transferred embryos, n | 148 | 199 | 316 | - |
| No. of embryo transfer cycles, n | 90 | 97 | 185 | - |
| No. of lost follow-up | 0 | 3 | 2 | |
| Implantation rate, % | 26.40 (39/148) | 23.20 (59/254) | 35.40 (112/316) | 0.004 |
| Clinical pregnancy rate, % | 36.70 (33/90) | 43.30 (42/97) | 49.70 (92/185) | 0.116 |
| EP | 1.1(1/90) | 1.0(1/97) | 1.1 (2/185) | 1.000** |
| Live birth rate, % | 26.70 (24/90) | 32.00 (31/97) | 40.50 (75/185) | 0.061 |
| Spontaneous abortion rate, % | 24.20 (8/33) | 16.70 (7/42) | 14.10 (13/92) | 0.411 |
| Premature delivery rate, % | 8.30 (2/24) | 25.80 (8/31) | 9.30 (7/75) | 0.073** |
| No. of newborns, n | 30 | 42 | 87 | |
| Weeks of gestation, wk | 38.14 ± 1.28 | 37.59 ± 2.11 | 38.45 ± 1.63 | 0.912 |
| Weight of singleton births, kg | 2.92 ± 0.30 | 3.06 ± 0.49 | 3.21 ± 0.71 | 0.189 |
| Weight of twin births, kg | 2.68 ± 0.46 | 2.39 ± 0.58 | 2.55 ± 0.24 | 0.162 |
| Newborn malformation rate, % | 3.3 (1/30) | 4.80 (2/42) | 0.00(0/95) | 0.078** |
Note: Data are presented as mean ± SD for continuous variables and % (n/N) for categorical variables
* P value calculated with χ2 test or t-test or ANOVA as appropriate
** P value calculated with fisher’s exact test