Table 1.
Top 50 upregulated circRNAs between NC and CCI rats
| cicName | Gene symbol | NC | CCI | Log2FoldChange | p value | q value |
|---|---|---|---|---|---|---|
| rat_circ:chr13:14728984–14734632 | * | 0.006613447 | 0.239134343 | 5.176275102 | 1.04E−05 | 0.000197339 |
| rat_circ:chr8:122024123–122051181 | * | 0.026453788 | 0.327144217 | 3.628380535 | 1.08E−05 | 0.000204393 |
| rat_circ:chr17:5142807–5148631 | * | 0.102932557 | 1.020292962 | 3.309212177 | 3.53E−14 | 1.92E-12 |
| rat_circ:chr3:16676098–16677678 | * | 0.038958884 | 0.357541925 | 3.198088158 | 1.75E−05 | 0.000311119 |
| rat_circ:chr10:83601126–83611053 | * | 0.048021776 | 0.409332141 | 3.091511283 | 5.04E−06 | 0.000100524 |
| rat_circ:chr4:133073964–133096725 | Shq1 | 0.079302196 | 0.557523925 | 2.813600993 | 4.06E−07 | 9.77E−06 |
| rat_circ:chr6:12442152–12468485 | Gtf2a1l | 0.158363447 | 1.090678555 | 2.783914689 | 4.89E−13 | 2.40E−11 |
| rat_circ:chr2:3165816–3262689 | * | 0.269462862 | 1.688134016 | 2.647271084 | 2.22E−16 | 1.41E−14 |
| rat_circ:chr4:127707965–127709016 | Suclg2 | 0.07789907 | 0.475982505 | 2.611230542 | 8.46E−06 | 0.000162135 |
| rat_circ:chr1:207212800–207228383 | Dock1 | 0.250908366 | 1.490557854 | 2.570619891 | 1.11E−15 | 6.95E−14 |
| rat_circ:chr12:628708–632694 | N4bp2l2 | 0.331660809 | 1.909515799 | 2.525426408 | 2.22E−16 | 1.41E−14 |
| rat_circ:chr9:98293254–98296809 | * | 0.075039684 | 0.426190004 | 2.505771094 | 1.13E−05 | 0.000211892 |
| rat_circ:chr6:103783216–103876906 | * | 0.095921747 | 0.536135335 | 2.482667387 | 1.41E−06 | 3.06E−05 |
| rat_circ:chr9:21359002–21381023 | * | 0.351886506 | 1.877364693 | 2.415526836 | 2.22E−16 | 1.41E−14 |
| rat_circ:chr13:42464681–42484505 | * | 0.461623763 | 2.428772129 | 2.395437745 | 2.22E−16 | 1.41E−14 |
| rat_circ:chr17:31092766–31111405 | * | 0.397313897 | 2.017431411 | 2.344168464 | 2.22E−16 | 1.41E−14 |
| rat_circ:chr18:15167501–15177828 | Mapre2 | 0.163508464 | 0.825898788 | 2.33659967 | 9.67E−09 | 3.04E−07 |
| rat_circ:chr1:115688753–115690048 | * | 0.084999051 | 0.422172726 | 2.312314733 | 6.00E−05 | 0.000921612 |
| rat_circ:chr1:132003515–132012253 | * | 0.122526404 | 0.60044185 | 2.292931859 | 1.19E−06 | 2.64E−05 |
| rat_circ:chr10:51399085–51420055 | * | 0.265527228 | 1.296441867 | 2.287625806 | 8.00E−13 | 3.83E−11 |
| rat_circ:chr10:51724607–51734014 | Myocd | 0.158230338 | 0.739399801 | 2.224328417 | 2.55E−07 | 6.38E−06 |
| rat_circ:chr18:13870389–13923877 | Nol4 | 0.311141127 | 1.410542522 | 2.18060915 | 4.60E−13 | 2.27E−11 |
| rat_circ:chr15:16089766–16170268 | Fhit | 0.174858821 | 0.791604402 | 2.178589054 | 1.11E−07 | 2.95E−06 |
| rat_circ:chr10:32437291–32442282 | Sgcd | 0.118076637 | 0.53278429 | 2.173828 | 1.13E−05 | 0.000211892 |
| rat_circ:chr4:129756394–129778825 | * | 0.173758692 | 0.772875498 | 2.153150883 | 1.75E−07 | 4.49E−06 |
| rat_circ:chr14:94275506–94356512 | * | 2.000034951 | 8.784498579 | 2.134934728 | 0 | 0 |
| rat_circ:chr10:77840596–77845575 | * | 0.184956873 | 0.804092283 | 2.120172172 | 1.87E−07 | 4.73E−06 |
| rat_circ:chr3:63039411–63058267 | Pde11a | 0.396002984 | 1.710669556 | 2.110977899 | 5.55E−15 | 3.28E−13 |
| rat_circ:chr7:64050812–64065194 | Srgap1 | 0.318355006 | 1.35773337 | 2.092491836 | 1.96E−11 | 8.20E−10 |
| rat_circ:chr17:56931036–56944178 | * | 0.441633884 | 1.843422885 | 2.061464294 | 1.78E−15 | 1.09E−13 |
| rat_circ:chr8:63507502–63540694 | Rec114 | 0.341030078 | 1.408824831 | 2.046521349 | 8.62E−12 | 3.74E−10 |
| rat_circ:chr11:59110328–59200801 | Lsamp | 1.853392371 | 7.635218572 | 2.042501119 | 0 | 0 |
| rat_circ:chr12:1509719–1512175 | Rn5s | 3.310525114 | 13.62707285 | 2.041343719 | 0 | 0 |
| rat_circ:chr2:84361142–84373051 | Ankrd33b | 0.281535995 | 1.155090346 | 2.036614408 | 3.41E−10 | 1.28E−08 |
| rat_circ:chr5:39149632–39157890 | * | 0.252422652 | 1.033033146 | 2.032973259 | 4.32E−09 | 1.41E−07 |
| rat_circ:chr7:103024404–103123226 | * | 2.133991155 | 8.708894234 | 2.028935355 | 0 | 0 |
| rat_circ:chr5:103284367–103352641 | Cntln | 0.135431589 | 0.551848363 | 2.026707619 | 2.05E−05 | 0.000354737 |
| rat_circ:chr2:39818337–39845931 | * | 0.769099545 | 3.108829149 | 2.01512909 | 0 | 0 |
| rat_circ:chr3:55157605–55224851 | * | 1.500202608 | 6.047257552 | 2.011123669 | 0 | 0 |
| rat_circ:chr5:49097739–49187150 | * | 1.842693006 | 7.359085633 | 1.997710785 | 0 | 0 |
| rat_circ:chr3:176137456–176143033 | * | 0.217785593 | 0.869089421 | 1.996596103 | 8.13E−08 | 2.22E−06 |
| rat_circ:chr5:106553499–106632351 | * | 1.36441395 | 5.442020732 | 1.995861042 | 0 | 0 |
| rat_circ:chr16:23448552–23492639 | * | 1.331199157 | 5.293003424 | 1.991360163 | 0 | 0 |
| rat_circ:chr4:108913081–108982246 | Ctnna2 | 1.818672104 | 7.064297787 | 1.957660702 | 0 | 0 |
| rat_circ:chr1:25216049–25284394 | Clvs2 | 1.338072701 | 5.168828573 | 1.949680852 | 0 | 0 |
| rat_circ:chr8:13085939–13095295 | * | 0.20772817 | 0.799366276 | 1.944159836 | 7.24E−07 | 1.68E−05 |
| rat_circ:chr8:110645275–110656857 | Ephb1 | 0.470472499 | 1.808594153 | 1.942686405 | 2.98E−14 | 1.63E−12 |
| rat_circ:chr7:135919861–135967388 | Tmem117 | 1.354011654 | 5.136609176 | 1.923576153 | 0 | 0 |
| rat_circ:chr8:130762665–130768360 | Snrk | 0.921667931 | 3.483545605 | 1.918237491 | 0 | 0 |
| rat_circ:chr17:29311092–29354416 | Fars2 | 0.834086166 | 3.147143806 | 1.915774767 | 0 | 0 |
Following differential expression analysis, 374 DEcircRNAs were identified between the CCI and NC groups (4 mice per group) by using FC filtering (FC ≥ 2 or ≤ 0.5) and FDR (Q < 0.001). The 50 up-regulated DEcircRNAs were listed