FIG 4.

Representative H&E-stained tissue sections from marmosets’ challenge with B. pseudomallei by various routes of exposure; they were either given placebo or relapsed following treatment with co-trimoxazole. Liver sections from a placebo animal following ingestion challenge showing mild lesions (×20) (a), or an animal that relapsed following treatment with co-trimoxazole and inhalational challenge showing moderate lesions (×20) (b). Spleen sections showing moderate lesions from a placebo animal following ingestion challenge (c), and an animal that relapsed following treatment with co-trimoxazole and inhalational challenge (d) (×20). Lung sections from animals following inhalational challenge that were given either placebo and presented with severe lesions (e) or treatment with co-trimoxazole showing mild, chronic lesions (f). Ileum (g) and cecum (i) sections showing the lack of lesions in a placebo animal challenged by the inhalational route compared to the mild (h) or moderate (j) lesions observed in the ileum and cecum, respectively, of an animal that relapsed following treatment with co-trimoxazole and inhalational challenge.