FIG 6.

Changes in cell populations and phenotype of the immune cells in animals that received placebo and succumbed following challenge with B. pseudomallei by various routes. Lymphocyte (a) and neutrophil and monocyte (b) profiles of changes between matched blood samples were compared to baseline levels for animals challenged by the inhalational (red), ingestion (green), or subcutaneous (blue) routes. Data are presented for each individual animal and grouped by challenge routes. The proportion (c) and expression (d) of neutrophils in the lung were compared to animals that relapsed (pink) or survived until the end of the study (black). The significant difference for combined routes determined by one sample t test for (a) and (b) and Kruskal-Wallis ANOVA for (c) and (d), where *, P < 0.05; **, P <0.01; ***, P < 0.001.