TABLE 1.
Manogepix frequency and cumulative percent inhibition against the main organisms and organism groups tested using the CLSI broth microdilution method
| Organism group or organism (no. of isolates) | No. (cumulative %) of isolates inhibited at MIC or MEC (mg/liter) ofa: |
MIC50 | MIC90 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.002 | 0.004 | 0.008 | 0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | >b | |||
| Candida spp. (1,072) | 29 (2.7) | 226 (23.8) | 313 (53.0) | 218 (73.3) | 150 (87.3) | 69 (93.8) | 13 (95.0) | 6 (95.5) | 2 (95.7) | 2 (95.9) | 1 (96.0) | 1 (96.1) | 5 (96.5) | 37 (100.0) | 0.008 | 0.06 |
| C. albicans (350) | 12 (3.4) | 178 (54.3) | 152 (97.7) | 6 (99.4) | 1 (99.7) | 0 (99.7) | 1 (100.0) | 0.004 | 0.008 | |||||||
| C. auris (11) | 3 (27.3) | 6 (81.8) | 0 (81.8) | 1 (90.9) | 1 (100.0) | 0.004 | 0.015 | |||||||||
| C. dubliniensis (40) | 5 (12.5) | 25 (75.0) | 10 (100.0) | 0.004 | 0.008 | |||||||||||
| C. glabrata (258) | 0 (0.0) | 1 (0.4) | 20 (8.1) | 54 (29.1) | 112 (72.5) | 62 (96.5) | 9 (100.0) | 0.03 | 0.06 | |||||||
| C. kefyr (10) | 0 (0.0) | 1 (10.0) | 2 (30.0) | 4 (70.0) | 1 (80.0) | 2 (100.0) | 0.25 | 1 | ||||||||
| C. krusei (45) | 0 (0.0) | 2 (4.4) | 0 (4.4) | 0 (4.4) | 0 (4.4) | 1 (6.7) | 5 (17.8) | 37 (100.0) | >8 | >8 | ||||||
| C. lusitaniae (16) | 0 (0.0) | 5 (31.2) | 7 (75.0) | 4 (100.0) | 0.03 | 0.06 | ||||||||||
| C. orthopsilosis (12) | 0 (0.0) | 7 (58.3) | 3 (83.3) | 2 (100.0) | 0.008 | 0.03 | ||||||||||
| C. parapsilosis (165) | 0 (0.0) | 4 (2.4) | 89 (56.4) | 58 (91.5) | 13 (99.4) | 1 (100.0) | 0.008 | 0.015 | ||||||||
| C. tropicalis (139) | 1 (0.7) | 6 (5.0) | 30 (26.6) | 89 (90.6) | 11 (98.6) | 1 (99.3) | 1 (100.0) | 0.015 | 0.015 | |||||||
| Other Candida spp. (24)c | 8 (33.3) | 5 (54.2) | 4 (70.8) | 2 (79.2) | 3 (91.7) | 0 (91.7) | 0 (91.7) | 0 (91.7) | 1 (95.8) | 0 (95.8) | 1 (100.0) | 0.004 | 0.03 | |||
| Cryptococcus neoformans var. grubii (27) | 0 (0.0) | 2 (7.4) | 5 (25.9) | 3 (37.0) | 2 (44.4) | 8 (74.1) | 7 (100.0) | 0.5 | 1 | |||||||
| Other Yeasts (26)d | 0 (0.0) | 3 (11.5) | 5 (30.8) | 7 (57.7) | 3 (69.2) | 1 (73.1) | 1 (76.9) | 1 (80.8) | 1 (84.6) | 0 (84.6) | 0 (84.6) | 0 (84.6) | 4 (100.0) | 0.03 | >8 | |
| Aspergillus spp. (246) | 0 (0.0) | 7 (2.8) | 47 (22.0) | 141 (79.3) | 45 (97.6) | 6 (100.0) | 0.015 | 0.03 | ||||||||
| A. fumigatus (169) | 0 (0.0) | 20 (11.8) | 110 (76.9) | 36 (98.2) | 3 (100.0) | 0.015 | 0.03 | |||||||||
| Aspergillus section Flavi (24) | 0 (0.0) | 3 (12.5) | 13 (66.7) | 5 (87.5) | 3 (100.0) | 0.015 | 0.06 | |||||||||
| Aspergillus section Nigri (27) | 0 (0.0) | 6 (22.2) | 14 (74.1) | 5 (92.6) | 2 (100.0) | 0.008 | 0.015 | |||||||||
| Aspergillus section Terrei (14) | 0 (0.0) | 1 (7.1) | 7 (57.1) | 5 (92.9) | 1 (100.0) | 0.008 | 0.015 | |||||||||
| Other Aspergillus spp. (12)e | 0 (0.0) | 3 (25.0) | 8 (91.7) | 1 (100.0) | 0.015 | 0.015 | ||||||||||
| Scedosporium spp. (12)f | 0 (0.0) | 3 (25.0) | 7 (83.3) | 1 (91.7) | 0 (91.7) | 1 (100.0) | 0.06 | 0.12 | ||||||||
| Other molds (52)g | 6 (11.5) | 9 (28.8) | 11 (50.0) | 8 (65.4) | 2 (69.2) | 3 (75.0) | 0 (75.0) | 2 (78.8) | 0 (78.8) | 2 (82.7) | 2 (86.5) | 3 (92.3) | 1 (94.2) | 3 (100.0) | 0.008 | 4 |
The 24-h MIC recorded for Candida spp., 48-h MIC recorded for other yeasts and C. neoformans var. grubii; 72-h MEC recorded for Scedosporium spp., or 48-h MEC recorded for Aspergillus spp. and other molds. Numbers in boldface are modal MIC values.
Greater than the highest dilution tested.
Organisms (number of isolates) include Candida bracarensis (2), C. duobushaemulonii (1), C. fermentati (2), C. guilliermondii (6), C. haemulonii (1), C. inconspicua (2), C. nivariensis (1), C. pelliculosa (4), C. rugosa (2), C. spencermartinsiae (1), and C. utilis (2).
Organisms (number of isolates) include Cryptococcus gattii species complex (1), C. neoformans var. neoformans (2), Saprochaete clavata (3), Kodamaea ohmeri (1), Magnusiomyces capitatus (1), Rhodotorula mucilaginosa (5), Saccharomyces cerevisiae (7), Trichosporon asahii (4), T. mycotoxinivorans (1), and Yarrowia lipolytica (1).
Organisms (number of isolates) include Aspergillus nidulans (6), A. nidulans species complex (2), A. sclerotiorum (1), A. ustus (1), A. ustus species complex (1), and A. versicolor (1).
Organisms (number of isolates) include Scedosporium apiospermum/Scedosporium boydii (9) and S. aurantiacum (3).
Organisms (number of isolates) include Exophiala dermatitidis (1), Fusarium incarnatum-equiseti species complex (1), F. solani (2), F. solani species complex (5), Gibberella fujikuroi species complex (6), Lichtheimia corymbifera (1), Lomentospora prolificans (4), Mucor circinelloides (2), M. indicus (1), Purpuriocillium lilacinum (2), P. variotii (7), Penicillium citrinum (1), P. onobense (1), Rasamsonia argillacea (1), R. argillacea species complex (3), Rhizopus microsporus group (4), R. oryzae (1), R. oryzae species complex (1), Sarocladium kiliense (1), Scopulariopsis brevicaulis (1), unspeciated Acremonium (1), unspeciated Coprinellus (1), unspeciated Cunninghamella (1), unspeciated Lichtheimia (1), unspeciated Paecilomyces (1), and unspeciated Trichoderma (1).