TABLE 6.
Summary of CYP alterations detected among non-wild-type Aspergillus spp. isolates in the 2020 international surveillance program
| Country | Organism | MIC data (mg/liter)a |
CYP alteration(s) |
||||
|---|---|---|---|---|---|---|---|
| Manogepix | Voriconazole | Itraconazole | Posaconazole | CYP51A | CYP51B | ||
| USA | A. fumigatus | 0.015 | 0.5 (WT) | 2 (NWT) | 0.25 (WT) | I242V | WT |
| USA | A. fumigatus | 0.06 | 1 (WT) | 2 (NWT) | 0.5 (WT) | WT | Q42L |
| USA | A. fumigatus | 0.015 | 0.5 (WT) | 2 (NWT) | 0.25 (WT) | WT | Q42L |
| USA | A. fumigatus | 0.03 | 0.5 (WT) | 2 (NWT) | 0.5 (WT) | N248K | WT |
| USA | A. fumigatus | 0.015 | 0.5 (WT) | 2 (NWT) | 0.5 (WT) | F46Y, M172V, N248T, D255E, E427K | WT |
| France | A. fumigatus | 0.06 | 1 (WT) | 4 (NWT) | 1 (NWT) | WT | Q42L |
| New Zealand | A. fumigatus | 0.03 | 8 (NWT) | >8 (NWT) | 8 (NWT) | G138C | WT |
| UK | A. fumigatus | 0.015 | 2 (NWT) | 4 (NWT) | 1 (NWT) | L98H, TR34 | WT |
| UK | A. fumigatus | 0.008 | 2 (NWT) | 4 (NWT) | 0.5 (WT) | L98H, TR34 | WT |
| UK | A. fumigatus | 0.008 | 2 (NWT) | 8 (NWT) | 1 (NWT) | L98H, TR34 | WT |
| USA | A. fumigatus | 0.015 | 0.5 (WT) | 2 (NWT) | 0.25 (WT) | I242V | WT |
a
Categorical interpretations of non-wild type (NWT) and wild type (WT) are according to ECVs from CLSI document M57 (24). The ECV for posaconazole was 0.5 mg/liter.