TABLE 5.
Pharmacokinetic/pharmacodynamic indices and clinical outcomes of 20 critically ill patients
| Parameter | Overall (n = 20)a |
Clinical outcome |
Survival during ICU admission |
||||
|---|---|---|---|---|---|---|---|
| Success (n = 13)a |
Failure (n = 7)a |
P value | Alive (n = 14)a |
Dead (n = 6)a |
P value | ||
| MIC (mg/L) | 0.023 to 32 | 0.032 (0.023 to 32) | 32 (12 to 32) | 0.001 | 0.07 (0.023 to 32) | 32 (12 to 32) | 0.003 |
| No. resistant pathogen (%) | 8 (40) | 1 (7.7) | 7 (100) | 0.001 | 2 (14.3) | 6 (100) | 0.001 |
| %fT>MIC | 100 (6.3 to 100) | 100 (50 to 100) | 81.3 (6.3 to 100) | 0.017 | 100 (6.3 to 100) | 85.6 (8.8 to 100) | 0.279 |
| fT>MIC ≥ 40% | 18 (90) | 13 (100) | 5 (71.4) | 0.111 | 13 (92.9) | 5 (83.3) | 0.521 |
| fT>MIC ≥ 75% | 14 (70) | 10 (76.9) | 4 (57.1) | 0.613 | 10 (71.4) | 4 (66.7) | 1.000 |
| fT>MIC = 100% | 11 (55) | 10 (76.9) | 1 (14.3) | 0.017 | 10 (71.4) | 1 (16.7) | 0.05 |
a
Data are presented as median (minimum-maximum) or n (%).