TABLE 3.
Suggested dosing schedules of ETI when coadministered with select NTM treatments
| NTM treatment | ETI and time of dose | Suggested ETI dose adjustments and transitionsa | ||||
|---|---|---|---|---|---|---|
| DOT 2 to 4 | DOT 5 to DPT 1 | DPT 2 to 7 | DPT 8 | |||
| Rifabutin, 300 mg daily | a.m. | Elexacaftor/tezacaftor/ivacaftor | 200/100/150 mg | 200/100/150 mg | 200/100/150 mg | Resumption of standard doseb |
| ivacaftor | 150 mg | 300 mg | 150 mg | |||
| p.m. | Elexacaftor/tezacaftor/ivacaftor | 100/50/75 mg | ||||
| Ivacaftor | 300 mg | 300 mg | 300 mg | |||
| DOT 3 to 23 | DOT 24 to DPT 9 | DPT 10 to 41 | DPT 42 | |||
| Clofazimine, 100 mg daily | Elexacaftor/tezacaftor/ivacaftor | 200/100/150 mg daily | 200/100/150 mg q48hc | 200/100/150 mg daily | Resumption of standard doseb | |
| Ivacaftor | 150 mg q48hc | |||||
| DOT 2 to DPT 3 | DPT 4 | |||||
| Clarithromycin, 500 mg q12h | Elexacaftor/tezacaftor/ivacaftor | 200/100/150 mg q72h | Resumption of standard doseb | |||
a
DOT, day of treatment; DPT, day posttreatment.
b
Standard dose consists of elexacaftor 200 mg/tezacaftor 100 mg/ivacaftor 150 mg a.m. plus ivacaftor 150 mg p.m.
c
Elexacaftor 200 mg/tezacaftor 100 mg/ivacaftor 150 mg alternating with ivacaftor 150 mg every other day.