Figure 1.

Landmark time points in RAS, BRAF, and MMR/MSI testing since 2012. The key time points used during the analysis are depicted in this figure for each biomarker evaluated (RAS, BRAF, and MMR/MSI). White boxes indicate NCCN guideline update, black boxes indicate landmark publications or presentations, and gray boxes indicated US FDA label change or approval. dMMR = deficient mismatch repair; EGFR = epidermal growth factor receptor; FDA = Food and Drug Administration; mAb = monoclonal antibody; mCRC = metastatic colorectal cancer; MMR = mismatch repair; MSI = microsatellite instability; MSI-H = microsatellite instability high; MT = mutated; NCCN = National Comprehensive Cancer Network; PD-1 = programmed death ligand 1; TP = time point; WT = wild type.