Table 3.
Comparison of biochemical measurements in subjects with familial partial lipodystrophy, FPLD3 and FPLD2
| FPLD3 | FPLD2 | |||||
|---|---|---|---|---|---|---|
| n | Value | n | Value | P value | P value adjusted for sex and age | |
| Sex (M/F) | 4/28 | 59/196 | .16 | NA | ||
| Age (y)a | 32 | 40.7 ± 17.2 | 255 | 36.8 ± 16.7 | .21 | NA |
| Height (cm)a | 28 | 163.4 ± 8.4 | 255 | 164.1 ± 13.8 | .81 | .94 |
| Weight (kg)a | 28 | 70.0 ± 15.7 | 255 | 69.8 ± 18.3 | .96 | .61 |
| BMI (kg/m2)a | 28 | 25.9 ± 3.9 | 255 | 25.5 ± 4.6 | .67 | .56 |
| HDL-Ca (mg/dL) | 25 | 30.5 ± 9.7 | 180 | 39.1 ± 12.4 | .001 | .0006 |
| LDL-Ca (mg/dL) | 19 | 69.6 ± 30.5 | 146 | 106.8 ± 37.2 | .0001 | .0001 |
| HbA1c (%)a | 28 | 7.5 ± 2.2 | 167 | 6.4 ± 1.8 | .006 | .012 |
| Cholesterol (mg/dL)b | 30 | 156 (80-429) | 186 | 191 (60-710) | .04 | .038 |
| Triglycerides (mg/dL)b | 30 | 255 (50-7919) | 189 | 208 (38-11528) | .018 | .04 |
| Glucose (mg/dL)b | 30 | 115 (50-355) | 181 | 95 (68-398) | .12 | .23 |
| ALT (U/L)b | 29 | 22 (8-59) | 55 | 27(10-130) | .43 | .51 |
| AST (U/L)b | 29 | 22 (12-68) | 55 | 22 (9-80) | .82 | .78 |
| ALP (U/L)b | 29 | 55 (29-344) | 51 | 62 (19-159) | .15 | .10 |
Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; NA, not applicable.
a
Data shown as mean ± SD.
b
Data skewed and shown as median (minimum and maximum values).