eTable 1. Overview of measurements and definitions of laboratory-chemical and clinical variables.
| Lab parameter / risk factor | Time of examination SHIP-0 |
| Total cholesterol serum concentration (mg/dL) | Photometric measurement in non-fasting serum sample by Hitachi 704 |
| HDL cholesterol serum concentration (mg/dL) | Precipitation with phosphotungstic acid/MgCl2 and subsequent cholesterol measurement in serum sample by EPOS 5060 |
| LDL cholesterol serum concentration (mg/dL) | Measurement using the Friedewald formula from values of total serum cholesterol-, HDL-, and triglyceride concentrations |
| Triglyceride serum concentration (mg/dL) | Enzymatic color test in serum sample by Hitachi 717 |
| HbA1c (%) | Photometric measurement in EDTA whole blood sample by Diamat (Biorad) |
| Systolic blood pressure | Mean value of the second and third blood pressure measurement (systolic pressure) (e1) |
| Treatment with antihypertensive drugs | Intake of medication based on the medication review with the AT codes C02A*,C03C*, C03E*, C09BA*,C07A*,C08C*, C09AA*, C09CA* |
| Diabetes mellitus | Self reported diabetes mellitus, in answer to the question: “Are you diabetic?” and “has this been diagnosed or confirmed by a doctor?” (e2) |
| Cigarette smoking | Self reported cigarette smoking, in answer to the question: “Do you currently smoke cigarettes?”; never-smokers and former smokers defined as current non-smokers on the basis of the question: “Have you ever smoked cigarettes?” (e3) |
| Familial predisposition for cardiovascular disorders | For all subjects, the absence of a cardiovascular familial predisposition was defined, as for the data collection, only myocardial infarctions were considered and the age at the time of the event was not recorded. |
HbA1c, hemoglobin A1c; HDL, high density lipoprotein; LDL, low density lipoprotein