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. 2022 Nov 15;50(2):1639–1653. doi: 10.1007/s11033-022-08075-9

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Fig. 3 — Apelin/APJ system promotes glioblastoma invasion. Apelin/APJ system promotes RGC aggregation for GBM growth via GSK-3β, the effect is promoted by hypoxia. GP130 regulates ARF to control apelin binding to APJ. GBM glioblastoma, RGC glioblastoma stem-like cell, GP130 glycoprotein 130, GSK-3β glycogen synthase kinase 3β