Fig. 9. Pam₂Cys Spike vaccination protects mice from damaging leukocyte infiltration of the lung parenchyma during SARS-CoV-2 infection.

a Quantitation of inflammatory cells in the lung parenchyma of vaccinated mice 7 days p.i, Pam₂Cys alone (P₂C; black), or Pam₂Cys Spike, sub-cutaneously (s.c; blue) or intra-nasally (i.n; red) Data are for individual mice (n = 5 each), means + /− SEM are shown. Statistics: p values indicated, Kruskal–Wallis test, Dunn’s multiple comparisons. Representative lung histological sections from mice 7 days p.i with SARS-CoV-2, vaccinated with (b) Pam₂Cys s.c, (c) Pam₂Cys Spike s.c, (d) Pam₂Cys i.n, a representative for both unprotected and protected phenotypes are shown, and e Pam₂Cys Spike i.n. Scale bar = 50 μm. Source data are provided as a Source Data file.