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. Author manuscript; available in PMC: 2022 Nov 14.
Published in final edited form as: JACC Clin Electrophysiol. 2022 Sep 28;8(10):1191–1215. doi: 10.1016/j.jacep.2022.07.003

FIGURE 5. 3-Dimensional Image of the Whole-Mount SAN Preparation Showing S100B+/GFAP− Cells.

FIGURE 5

Three-dimensional reconstruction of the SAN from the SVC (right) to the IVC (left) and from the septum (SPT) (bottom) to the right auricle (RA) (top) 4.5 mm long, 3.5 mm wide, and 250 μm deep. Novel S100B+ (cyan)/GFAP− (green) cells were detected within the HCN4+ meshwork (red). The RA lacks S100B+ (cyan)/GFAP− (green) interstitial cells. Dotted line indicates the border of crista terminalis (CT). Abbreviations as in Figures 1 and 4.