Figure 4.

Candidate ICR for DHRSX (ICR_1394) in the pseudo autosomal region, PAR1, on the X chromosome; visualize at https://humanicr.org/. Whole genome bisulphite sequencing (WGBS) identified a candidate ICR (red box) in embryonic brain, kidney, and liver tissue for a candidate imprinted gene associated with starvation induced autophagy [45]. DNA methylation determined by WGBS in sperm and oocytes is also shown; these sequence data were supplemented with publicly available gametic sequence (accession number JGAS00000000006) and part of control sperm data from PRJNA754049 [25,26]. Dots indicate hemi-methylation (green), hypomethylation (blue) and hypermethylation (yellow) based on WGBS. The vertical dashed red lines delineate the candidate ICR regions.