Table 5.
Summary of significantly enriched pathways and GO terms (q < 0.10) involved in neuronal, developmental, and cellular signalling processes. Candidate gene set comprised of genes annotated to the top 250 differentially hydroxymethylated CpGs by Pb quantified in maternal toenail, infant toenail, and placenta.
| Pathway ID/GO Term | Pathway description/Term name | q-value |
|---|---|---|
| Maternal toenail | ||
| GO:0098794 | Postsynapse | 0.0799 |
| GO:0050807 | Regulation of synapse organization | 0.0835 |
| GO:0050803 | Regulation of synapse structure or activity | 0.0885 |
| Infant toenail | ||
| WP4816a | TGF-beta receptor signalling in skeletal dysplasias | 0.0680 |
| path:hsa05220b | Chronic myeloid leukaemia – Homo sapiens (human) | 0.0680 |
| WP560a | TGF-beta Receptor Signalling | 0.0680 |
| GO:0034673 | Inhibin-betaglycan-ActRII complex | 0.0193 |
| GO:0048185 | Activin binding | 0.0218 |
| GO:0046332 | SMAD binding | 0.0254 |
| GO:0004674 | Protein serine/threonine kinase activity | 0.0264 |
| GO:0004675 | Transmembrane receptor protein serine/threonine kinase activity | 0.0279 |
| Placenta | ||
| GO:0035904 | Aorta development | 0.0218 |
aPathway source: Wikipathways; b Pathway source: KEGG