FIG. 1.
Evidence for specific CTL response against Y. pseudotuberculosis in HLA-B27/hβ2m transgenic rats. (A) LN cells from an 21-4L rat infected i.p. with Y. pseudotuberculosis IP2777(pYV+) were restimulated in vitro with nontransgenic LEW LN cells infected with IP2777(pYV+). CTLs were tested 5 days later for lysis of LEW ConA blast (circles) and BMDM (squares) targets infected in vitro with IP2777 (pYV+) (solid symbols) or uninfected (open symbols). (B) LN cells from an 21-4L rat infected intragastrically with strain IP2777(pYV+) were restimulated in vitro with 21-4L LN cells infected with IP2777(pYV+) and tested for lysis of 21-4L lymphoblast targets uninfected (open circles) or infected with IP2777(pYV+) (solid circles), plasmid-cured strain IP2777c(pYV−) (solid squares), S. typhimurium (open triangles), or E. coli (open squares).