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. 1999 Aug;67(8):3773–3779. doi: 10.1128/iai.67.8.3773-3779.1999

FIG. 2.

FIG. 2

The anti-Y. pseudotuberculosis CTL response in 21-4L rats is mediated by CD8+ T cells and is genetically restricted. (A) LN cells from an 21-4L rat infected i.p. with Y. pseudotuberculosis IP2777(pYV+) were restimulated in vitro with 21-4L LN cells infected with IP2777(pYV+) and tested for lysis of 21-4L targets infected with IP2777(pYV+) (closed symbols) or uninfected (open symbols). Immunomagnetic sorting was performed to negatively select for all the T cells (squares), CD8+ T cells (diamonds), and CD4+ T cells (triangles), that were compared to unsorted cells (circles). (B) LN cells from a 21-4L rat infected i.p. with strain IP2777(pYV+) were restimulated in vitro with 21-4L LN cells infected with IP2777(pYV+) and tested for lysis of nontransgenic LEW (circles), 21-4L (squares), or BN (triangles) lymphoblast targets infected with strain IP2777(pYV+) (closed symbols) or uninfected (open symbols).