TABLE 1.
Protein origin | Peptide sequence | Scored | Reference |
---|---|---|---|
Yop protein | |||
YopO (previously YpkA) | KTYRIIDNQV | 9,000 | 15 |
YopH | QRFGMPDYF | 5,000 | 8 |
YopE | QRMFSEGSHK | 2,000 | 14 |
YopD | TRHEAQAIK | 2,000 | 17 |
YopJ | IRTKTAIER | 1,000 | 15 |
Known HLA-B27-binding motifb | |||
Human translation factor eIF2 | KRFEKHWRL | 30,000 | 6 |
Human proteasome subunit C5 | RRFMPYYVY | 15,000 | 6 |
Human immunodeficiency virus type 1 gp120 | GRAFVTIGK | 2,000 | 6 |
Rat H-Y Ag | KQYQKSTER | 1,500 | 41 |
Human ribosomal protein S25 | HRAQVIYTR | 1,000 | 6 |
Control sequencec | |||
HLA-A29 endogenous ligand | KEFQEHYEY | 225 | 6 |
Putative HLA-B*2705-binding 9- or 10-mer peptides carried by Y. pseudotuberculosis Yop proteins were identified by using the HLA Peptide Binding Predictions program (4a). Only one selected sequence with the highest estimate score is shown for each Yop tested.
Scores derived with the same program for several known HLA-B*2705-binding sequences.
Score derived with the same program for a non-HLA-B27-binding sequence.