TABLE 1.

Putative HLA-B^*2705-binding epitopes in Y. pseudotuberculosis Yop proteins^a

Protein origin	Peptide sequence	Scored	Reference
Yop protein
YopO (previously YpkA)	KTYRIIDNQV	9,000	15
YopH	QRFGMPDYF	5,000	8
YopE	QRMFSEGSHK	2,000	14
YopD	TRHEAQAIK	2,000	17
YopJ	IRTKTAIER	1,000	15
Known HLA-B27-binding motifb
Human translation factor eIF2	KRFEKHWRL	30,000	6
Human proteasome subunit C5	RRFMPYYVY	15,000	6
Human immunodeficiency virus type 1 gp120	GRAFVTIGK	2,000	6
Rat H-Y Ag	KQYQKSTER	1,500	41
Human ribosomal protein S25	HRAQVIYTR	1,000	6
Control sequencec
HLA-A29 endogenous ligand	KEFQEHYEY	225	6

^aPutative HLA-B*2705-binding 9- or 10-mer peptides carried by Y. pseudotuberculosis Yop proteins were identified by using the HLA Peptide Binding Predictions program (4a). Only one selected sequence with the highest estimate score is shown for each Yop tested. 

^bScores derived with the same program for several known HLA-B*2705-binding sequences. 

^cScore derived with the same program for a non-HLA-B27-binding sequence. 

^dEstimate of the half-time (in minutes) of dissociation of HLA-B*2705 molecule complexes containing the peptide as a result of calculations, based on the observed anchor residues preferences (32, 33, 36).