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. 2022 Nov 15;17(11):e0277706. doi: 10.1371/journal.pone.0277706

Table 2. Changes in absolute values of non-invasive tests over time.

LFS LAP NFS FIB-4
Visits (months) Aleglitazar Placebo Aleglitazar Placebo Aleglitazar Placebo Aleglitazar Placebo
0 N = 3,057
0.63 (0.57, 0.69)
N = 3,015
0.60 (0.56, 0.66)
N = 3,496
67.8 (66.2, 69.5)
N = 3,478
69.5 (67.3, 71.6)
N = 3,234
-0.41 (-0.45, -0.37)
N = 3,240
-0.50 (-0.56, -0.40)
N = 3,250
1.44 (1.42, 1.46)
N = 3,261
1.40 (1.38, 1.42)
3 N = 2,877
0.17 (0.13, 0.20)
N = 2,855
0.63 (0.57, 0.70)
Not available
Not available
N = 3,057
-0.59 (-0.63, -0.55)
N = 3,020
-0.29 (-0.33, -0.25)
N = 3,080
1.11 (1.09, 1.13)
N = 3,047
1.41 (1.39, 1.43)
6 N = 2,743
0.19 (0.16, 0.23)
N = 2,761
0.66 (0.59, 0.72)
N = 3,066
51.0 (49.2, 52.8)
N = 3,096
78.3 (75.5, 81.0)
N = 2,909
-0.54 (-0.58, -0.50)
N = 2,943
-0.31 (-0.35, -0.27)
N = 2,931
1.10 (1.08, 1.12)
N = 2,964
1.39 (1.37, 1.41)
12 N = 2,620
0.20 (0.15, 0.23)
N = 2,674
0.68 (0.62, 0.74)
N = 2,932
55.4 (53.8, 57.0)
N = 2,994
80.4 (77.8, 83.0)
N = 2,765
-0.50 (-0.54, -0.46)
N = 2,818
-0.25 (-0.29, -0.21)
N = 2,786
1.10 (1.08, 1.12)
N = 2,840
1.44 (1.42, 1.46)
24 N = 1,634
0.22 (0.17, 0.28)
N = 1,707
0.67 (0.61, 0.75)
N = 1,725
60.7 (58.3, 63.1)
N = 1,783
83.8 (80.3, 87.4)
N = 1,720
-0.37 (-0.43, -0.31)
N = 1,799
-0.20 (-0.26, -0.14)
N = 1,731
1.16 (1.14, 1.18)
N = 1,817
1.47 (1.43, 1.51)

†LFS = liver fat score; LAP = liver accumulation product; NFS = Non-alcoholic fatty liver disease fibrosis score; FIB-4 = fibrosis 4 calculator.

‡ Values of LFS are presented as median (distribution free 95% CI) and values of LAP, NFS and FIB-4 as mean (95% CI).