Figure 4.

Performance of the 9-mRNA signature combined with age to predict 28-day survival status in critically ill COVID-19 patients at ICU admission. (A) Area Under the Receiver Operating Characteristics curve (AUC) calculated on the training dataset of 216 patients and the independent test set of 93 critically ill COVID-19 patients using the 9-mRNA panel along with the age at their admission in ICU. The 95% confidence interval (grey) is calculated using bootstrap with 1000 repetitions. (B) Probability of 28-day mortality from linear SVM model trained on 9-gene panel (left) and 9-gene panel combined with age (right) on the entire cohort (n=309) of patients and healthy donors (n=49). p-values were generated using a Mann-Whitney-Wilcoxon test between survivors and non-survivors.