Figure 5.

Differential effects of age and memory in structural MRI and fMRI. Significant differences (A) between “young” and “old” older subjects and (B) between older subjects with higher versus lower memory performance, with respect to fMRI activity during novelty processing (first row), subsequent memory (second row), fMRI amplitudes during rest (third row), and voxel-wise gray matter volume (fourth row). Thresholded SPMs are FWE-corrected for cluster size (CDT: p < 0.001, k = 0). Colored voxels indicate significantly higher values for either young subjects and those with higher memory performance (red) or old subjects and those with lower memory performance (blue). For distributions of chronological age and memory performance underlying these analyses, see Extended Data Figure 5-1.