A, Schematic represents distinct and overlapping populations of SST-INs in mPFC (ACNP 60th Annual Meeting, 2021; Cummings et al., 2022). B, Schematic represents simplified connectivity motifs between superficial (Calb+) and deep (Calb-lacking) pyramidal neurons in vHPC with downstream mPFC neuron types (Sánchez-Bellot et al., 2022), and between long-range GABAergic neurons in mPFC with VIP-INs in dHPC (Malik et al., 2022). SST-INs, somatostatin-positive interneurons; dHPC, dorsal hippocampus; mPFC, medial prefrontal cortex; PN, pyramidal neurons; FSI, fast-spiking interneurons; ISI, irregular-spiking interneurons; RSI, regular-spiking interneurons. Created with www.BioRender.com.