Table 3. Univariate and multivariate analysis for PFS.

Variables	Category	PFS univariate			PFS multivariate
		HR.	CI	p	HR	CI	p
Age (years)	<50	1
	>50	1.17	0.68–2.02	0.563
De novo	No	1
	Yes	0.66	0.39–1.11	0.11
PS	<2	1
	≥2	1.08.	0.64–1.83	0.75
Lung	No	1
	Yes	1.23.	0.77–1.9	0.37
Liver	No	1
	Yes	2.39	1.4–4.05	0.01	2.09	1.22–3.58	0.007
Bone	No	1
	Yes	0.88	0.52–1.4	0.65
Pleura	No	1
	Yes	0.85.	0.48–1.5	0.58
Node	No	1
	Yes	1.10	0.688–1.78	0.67
ER score	Low	1
	High	0.48	0.27–1.4	0.08
Pr score	Low	1
	High	0.65	0.48–0.87	0.05	0.66	0.49–0.9	0.009
Line		First	1
	Beyond first	2.07	1.18–3.64.	0.011	2.07	1.18–3.66	0.011
Menopausal	Premenopausal	1
status	Postmenopausal	0.9	0.5–1.63	0 75