FIGURE 6.

Identification of the right CKD target. The target identification and validation framework relies on multiple data sources and validation models, integrating many disease-relevant data sets, to create a holistic scientific understanding of the mechanisms that link the target to disease biology. The in-depth scientific understanding of pathophysiology and target link to disease is, in our view, essential for delivering successful medicines to patients with CKD in the future. AI, artificial intelligence; CKD, chronic kidney disease; PD, pharmacodynamics; SME, subject-matter expert.