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. 2022 Nov 2;9:971592. doi: 10.3389/fcvm.2022.971592

TABLE 3.

Cost distribution of heart failure patients categorised based on left ventricular function.

Setting Cost component HFrEF (EF ≤ 40%), n = 263 HFmrEF (EF 41–49%), n = 34 HFpEF (EF ≥ 50%), n = 32



Cost PPPY, (USD)
mean (SD),
median (quartilesa)
% of cost
PPPYb
Cost PPPY, (USD)
mean (SD),
median (quartilesa)
% of cost
PPPY b
Cost PPPY, (USD)
mean (SD),
median (quartilesa)
% of cost
PPPYb
Outpatient, n = 329 Clinic Visits 116 (77) 6.1 110 (49) 4.4 107 (96) 4.4
97 (65, 162) 97 (65, 129) 97 (65, 129)
Medications (tablets/capsules/vials/ampoules) 210 (280) 11.0 243 (281) 9.8 172 (201) 7.1
102 (63, 182) 129 (77, 304) 100 (60, 185)
Diagnostic Tests 164 (157) 8.6 203 (175) 8.2 233 (223) 9.7
121(43, 231) 174 (49, 301) 228 (32, 413)
Total 489 (353) 25.6 556 (333) 22.5 512 (326) 21.2
395 (233, 644) 460 (353, 708) 445 (258, 634)
Inpatient, n = 101 Hospitalisations (bed-day) 413 (415) 21.7 299 (160) 12.1 657 (519) 27.3
305 (210, 445) 305 (235, 396) 541 (300, 717)
Medications (tablets/capsules/vials/ampoules) 20 (48) 1.0 13 (20) 0.5 178 (353) 7.4
3 (1, 18) 5 (2, 12) 24(20, 85)
Diagnostic Tests 410 (271) 21.5 437 (121) 17.7 576 (649) 23.9
379 (214, 519) 390 (351, 539) 330 (154, 664)
Procedures 577 (1,527) 30.2 1,166 (1,597) 47.2 486 (1,190) 20.2
0 (0, 0) 0 (0, 2,915) 0 (0, 0)
Total 1,420 (1,795) 74.4 1,916 (1,686) 77.5 1,898 (1,985) 78.8
662 (522, 1,206) 846 (818, 3,544) 983 (474, 2,962)
Total cost PPPY, (USD)
Mean (SD) 1,909 (1,291) 100 2,471 (991) 100 2,410 (1,226) 100
Median (quartilesa) 600 (294, 1,025) 514 (367, 837) 492 (279, 739)

EF, ejection fraction; HFmrEF, heart failure with mildly reduced ejection fraction; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; PPPY, per patient per year; USD, United States dollar; SD, standard deviation.

aFirst quartile and third quartile were used to describe the distribution of the cost because the costs were skewed to the right.

bPercentage of cost per patient per year was generated for mean cost only.

USD 1 = RM 4.134.