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. 2022 Nov 2;16:1023267. doi: 10.3389/fncel.2022.1023267

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Copyright © 2022 Hoff, Neumann and Moore.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Depiction of the development of the cerebral cortex. (A) Neural progenitor cells (blue) undergo symmetric and asymmetric divisions before differentiating into specific cell populations, such as neurons (orange). (B) Neurons radially migrate along glial cells from the ventricular zone (VZ) to the cortical plate (CP). Neurons are bipolar in the VZ before switching to a multipolar state in the subventricular zone (SVZ). To continue radial migration, neurons then revert back to a bipolar state through the intermediate zone (IZ) until they reach the developing CP. (C) Upon reaching the CP, neurons undergo further morphogenesis, including maturation of the axon and extension of multiple dendrites.