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. 2022 Nov 15;13:6981. doi: 10.1038/s41467-022-34730-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Progenitor cell composition of D5 aggregates obtained through temporal modulation of WNT signaling. b Structural organization and different cell populations present in PE/STM/PFH organoids highlighting the critical signaling pathways that should be activated during PE induction period (D5-D7) to generate those organoids. c Structural organization and different cell populations present in organoids generated through modulation of WNT, BMP4, and RA during PE induction period. Green spheres indicate activated signal and red spheres indicate not activated signal. d Co-culture process for the generation of EMOs, and identification of the different regions/cell populations present in EMOs. MZ myocardium-like zone, EL epicardial-like layer.