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. 2022 Nov 15;5:1253. doi: 10.1038/s42003-022-03981-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Bi-parametric dot plots showing the host cell and parasite survival as a percentage of DMSO-treated controls. Only two MMV compounds decreased host and parasite cell survival effectively, while the other 7 caused increased parasite numbers. This is probably due to the stress caused by drug cytotoxicity of host cells and the impact on parasites in the remaining surviving cells. The DMSO control (Ctrl) and Buparvaquone (Bup) data are shown for comparison. b Violin plots of the number of parasites per host cell. Data are shown for untreated, DMSO-treated, buparvaquone (Bup)-treated and hit compound-treated samples. Only one drug (MMV688754) showed a strong decrease in parasite number comparable to Buparvaquone treatment. The relative surviving host cell numbers are indicated above. The red dot represents the median number of parasites per surviving host cell, the boxplot shows the 1st and 3rd quartiles. The Buparvaquone drug is shown in brown and the two compounds MMV688372 and MMV688754 used in subsequent experiments are colored orange.