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. 2022 Nov 15;13:6977. doi: 10.1038/s41467-022-33765-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Homeostatic cGAS activity drives STING trafficking that supports the basal level of immune defense and maintains a healthy state. cGas^−/− cells and mice have lowered basal immune defense, leading to infection risk. Interruption of STING post-Golgi trafficking by Gcc2^−/− and Rab14^−/− leads to tonic IFN activation, increased autoimmunity and anti-tumor immunity.